Details

Project TitleAssay for Serum Bactericidal Activity Against N. Meningitidis
Track CodeUMMS09-17
Websitehttps://patents.google.com/patent/US8476032B2/en
Short Description

This patented invention discloses an assay method for detecting anti-Neisseria antibodies. Human factor H (fH) is a virulence factor that helps Neisseria to resist complement-mediated killing, thus circumventi

Abstract

This invention discloses an assay method for detecting anti-Neisseria antibodies. Human factor H (fH) is a virulence factor that helps Neisseria to resist complement-mediated killing, thus circumventing the host's innate immune response. Higher serum fH levels may correlate to patient susceptibility to infection. Neisserial factor H binding protein (fHBp) can be hindered by a human amino acid sequence revealed in the present technology, to facilitate accurate detection of Neisseria that exceeds the capability of existing methods. A reaction mixture containing bactericidal anti-Neisseria antibodies, a fH polypeptide comprising an amino acid sequence of human Short Consensus Repeat 6 sources of non human complement (SCR), and a Neisseria bacterium. This invention additionally discloses an animal model of Neisseria infection.

 
TagsAntibiotics/Antibiotic treatment, N. meningtitidis, vaccines, new antibody treatment
 
Posted DateJan 24, 2017 2:58 PM

Researcher

Name
Sanjay Ram
Dan Granoff
Jo Anne Welsch

Manager

Name
Kevin Lehman

Intellectual Property

Patent Number Issue Date Type Country of Filing
None None Other Patent None