Details

Project TitlePISA (Pyhin Protein Stimulating ASC) Triggers Inflammasome Activation in Response to Cytosolic B-DNA
Track CodeUMMS09-11
Websitehttps://patents.google.com/patent/US8334101B2/en
Short Description

This patented invention discloses methods for identification and compounds found to modulate the PISA receptor and it's downstream immune response. The innate immune system recognizes non-self genetic material and mounts a defensive immune response. However, self cytosolic DNA at times gets targeted and the process by which this phenomenon occurs

Abstract

The innate immune system recognizes non-self genetic material and mounts a defensive immune response. However, self cytosolic DNA at times gets targeted and the process by which this phenomenon occurs has been largely unknown. The inventors have discovered PISA (PYHIN protein stimulating ASC), a receptor found to be necessary for activation of the ACS/caspase-1 axis of innate immunity in response to recognition of self cytosolic DNA. 

 
Tagsinnate immunity
 
Posted DateJan 24, 2017 1:33 PM

Researcher

Name
Eicke Latz
Kate Fitzgerald
Veit Hornung

Manager

Name
Kevin Lehman

Intellectual Property

Patent Number Issue Date Type Country of Filing
None None Other Patent None